Despite remarkable advances in the treatment of B-cell acute lymphoblastic leukemia (B-ALL), racial/ethnic disparities in incidence and outcomes persist, suggesting inherited genetic differences in leukemia susceptibility and prognosis. Although African…
Understanding the causes of childhood leukemia—the most common cancer among children—remains a global research priority. Studies have identified abnormal chromosomes—extra, missing, or structurally rearranged—in cells at birth in most childhood…
Traditional epidemiological studies come with a variety of biases: recall bias, social desirability bias, and selection bias to name a few. CLIC partners from the United Kingdom, Drs. Audrey Bonaventure,…
In June 2025, two of our CLIC partners, Drs. Michael Scheurer and Joseph Wiemels joined a team of scientists at the International Agency for Research on Cancer (IARC) to discuss…
Building genomic datasets (i.e. genomewide association studies, GWAS) for childhood cancer is a lot of work. Childhood cancer is thankfully rare, so often GWAS datasets must be cobbled together with…
Wilms Tumor (WT), a solid tumor in the kidney, is the fourth most common cancer in children. Pediatric cancer researchers agree that WT is commonly found in young children before…
CLIC researchers Drs. Anssi Auvinen and Wafa Alimam, Tampere University-Finland, recently published a systematic review of studies on radioactive particles found in drinking water and cancer risk. Occasionally, naturally occurring…
You may have heard of genomewide association studies (GWAS), which discover genetic variants associated with disease. Phenome-wide association studies (PheWAS) flip the analysis and discover diseases or traits (i.e. phenotypes)…
Cancer registry data makes clear that children of different ancestries can have different risks of ALL. How much of this risk is due to genetics versus environment? CLIC researchers from…
Folate is an important micronutrient for a mother and baby’s health during pregnancy. CLIC studies show that the risk of childhood leukemia is reduced for children if their mothers took…
