Ewing sarcoma is a rare and aggressive cancer that primarily affects the bones and soft tissues of children and adolescents. The disease is characterized by a chromosomal translocation involving the…
Childhood acute lymphoblastic leukemia (ALL) has been widely postulated to originate before birth through early genetic lesions, followed by postnatal immune triggers. One of the most intriguing clues about this…
The genetic makeup of Hispanic/Latino populations reflects varying contributions from Indigenous American, European, and African ancestry, shaped by the complex demographic history of Latin America. Previous studies have suggested that…
A recent nationwide study conducted by CLIC partners has suggested that maternal use of nitrosatable drugs during pregnancy may be associated with modestly elevated risks of several rare childhood cancers,…
Despite remarkable advances in the treatment of B-cell acute lymphoblastic leukemia (B-ALL), racial/ethnic disparities in incidence and outcomes persist, suggesting inherited genetic differences in leukemia susceptibility and prognosis. Although African…
Understanding the causes of childhood leukemia—the most common cancer among children—remains a global research priority. Studies have identified abnormal chromosomes—extra, missing, or structurally rearranged—in cells at birth in most childhood…
Traditional epidemiological studies come with a variety of biases: recall bias, social desirability bias, and selection bias to name a few. CLIC partners from the United Kingdom, Drs. Audrey Bonaventure,…
In June 2025, two of our CLIC partners, Drs. Michael Scheurer and Joseph Wiemels joined a team of scientists at the International Agency for Research on Cancer (IARC) to discuss…
Building genomic datasets (i.e. genomewide association studies, GWAS) for childhood cancer is a lot of work. Childhood cancer is thankfully rare, so often GWAS datasets must be cobbled together with…
Wilms Tumor (WT), a solid tumor in the kidney, is the fourth most common cancer in children. Pediatric cancer researchers agree that WT is commonly found in young children before…
