Childhood sarcomas are a diverse group of rare cancers arising in bone and soft tissue, encompassing biologically distinct diseases such as osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma. While congenital anomalies are…
The causes of childhood lymphoma remain poorly understood. Unlike many other childhood cancers, lymphoma comprises a group disease that includes two main subtypes: Hodgkin lymphoma and non-Hodgkin lymphoma. These subtypes differ in their biology and etiology. Early-life environmental…
Per- and polyfluoroalkyl substances (PFAS), often called “forever chemicals,” are a large group of persistent chemicals used in products such as non-stick cookware, water-resistant materials, food packaging, and firefighting foams. Because…
Rates of childhood cancer are often reported to be lower in low-income countries, a pattern that has long been attributed to underdiagnosis or incomplete cancer registration. A new study from…
Ewing sarcoma is a rare and aggressive cancer that primarily affects the bones and soft tissues of children and adolescents. The disease is characterized by a chromosomal translocation involving the…
Childhood acute lymphoblastic leukemia (ALL) has been widely postulated to originate before birth through early genetic lesions, followed by postnatal immune triggers. One of the most intriguing clues about this…
The genetic makeup of Hispanic/Latino populations reflects varying contributions from Indigenous American, European, and African ancestry, shaped by the complex demographic history of Latin America. Previous studies have suggested that…
A recent nationwide study conducted by CLIC partners has suggested that maternal use of nitrosatable drugs during pregnancy may be associated with modestly elevated risks of several rare childhood cancers,…
Despite remarkable advances in the treatment of B-cell acute lymphoblastic leukemia (B-ALL), racial/ethnic disparities in incidence and outcomes persist, suggesting inherited genetic differences in leukemia susceptibility and prognosis. Although African…
Understanding the causes of childhood leukemia—the most common cancer among children—remains a global research priority. Studies have identified abnormal chromosomes—extra, missing, or structurally rearranged—in cells at birth in most childhood…
